Altamira Therapeutic’s RNA Delivery Platform Shown to be an Effective Treatment for Abdominal Aortic Aneurysm as Published in Peer-Reviewed Journal

  • Study results appeared in “Biomaterials Advances”, a highly respected peer-reviewed journal, showcasing growing medical recognition of Company’s patented RNA delivery platform for extrahepatic targets.
  • Company’s RNA delivery platform demonstrated effectiveness in mitigating abdominal aortic aneurysm progression and rupture in murine model.

HAMILTON, BERMUDA / ACCESSWIRE / July 12, 2022 / Altamira Therapeutics (“Altamira” or the “Company”) (NASDAQ:CYTO), a company dedicated to developing therapeutics that address important unmet medical needs, today announced the publication of a peer-reviewed article in the scientific journal Biomaterials Advances titled, “Peptide-siRNA nanoparticles targeting NF-κB p50 mitigate experimental abdominal aortic aneurysm (AAA) progression and rupture” that covers a study conducted by a research group at Washington University, St. Louis, MO.

The article, which was co-authored by Altamira’s Chief Scientific Officer, Samuel Wickline, MD, reported the study’s key findings that the Company’s peptide-based OligoPhore™ delivery platform using siRNA is effective in mitigating abdominal aortic aneurysm (AAA) progression and rupture in a preclinical murine model study. The study was designed, conducted, and analyzed independently of Altamira, and sponsored in part by research grants from the National Institutes of Health and the Veterans Administration. The peptide-based RNA delivery platform was invented at Washington University and licensed to Altamira, which is now under development as OligoPhore for delivery of siRNA and as SemaPhore™ for mRNA.

Abdominal Aortic Aneurysm is a Severe Condition Lacking Non-Surgical Treatment Options

AAA is a progressive vascular condition that accounts for approximately 15,000 deaths per year in the United States due to rupture. AAA is an inflammatory process with excessive local production of extracellular matrix degrading enzymes, leading to dilatation and rupture of the abdominal aorta. AAA is a complex disease associated with male gender, advanced age, hypertension, hypercholesterolemia, coronary artery disease, atherosclerosis, and cigarette smoking. Presently, open surgical repair of large AAA is an effective option in preventing death from rupture. Although effective, open surgical repair is recommended only for large aneurysms and can be associated with high post-operative mortality. Given the high mortality rate associated with surgical treatment, and the advanced age of patients with AAA, which may preclude them from undergoing major surgery, medical treatment represents an attractive alternative approach. However, at present there is no medical therapy specific to the fundamental disease process and standard of care is primarily supportive with cholesterol lowering agents and beta blockers.

Study Highlights

The study identified the NF-κB p50 and p65 subunits as key modulators of the inflammatory process contributing to the development of AAA. The knockdown of NF-κB subunits using siRNA delivered by Altamira’s peptide-based nanoparticles was shown to mitigate aneurysm progression and rupture in two different experimental models. Since the p50 knockdown was more effective at preventing rupture, the article discussed that p50 represents a preferable target for rational drug design in AAA treatment since it lacks a transactivating domain and its knockdown may carry less risk of adverse effects.

“This study’s results reinforce our hypotheses that the NF-κB pathway, with both p50 and p65 subunits contributing, is a primary driver of potentially lethal or severe inflammatory conditions and, accordingly, present high-value targets for our patented peptide-based delivery platform,” said Dr. Wickline. “We are strongly encouraged by the findings of this study and see this as an important milestone as we advance our RNA delivery platform technology to suppress the critical molecular drivers of inflammatory vascular diseases.

“Our patented OligoPhore platform for extrahepatic delivery of nucleotide therapeutics offers significant potential for the treatment of AAA and other inflammatory indications that currently lack safe or low-risk efficacious therapeutics,” Dr. Wickline added.

About Biomaterial Advances

Biomaterials Advances sits within Elsevier’s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility.

The journal publishes on topics at the interface of the biomedical sciences and materials engineering.

For more information, visit: https://www.journals.elsevier.com/biomaterials-advances

About OligoPhore

OligoPhore is a versatile platform for safe and effective delivery of oligonucleotides such as siRNA (small interfering ribonucleic acid) into target cells. It is based on a proprietary 21 amino acid peptide that can engage any type of RNA in rapid self-assembly into a polyplex. The polyplex has a size, charge, and other physical features that allow it to escape hepatic clearance and thus to reach other target tissues than the liver. OligoPhore protects the RNA payload from degradation in the circulation and allows for rapid cellular uptake, while enabling pH-dependent nucleotide endosomal escape and cytoplasmic delivery. Effective delivery and positive treatment outcomes have been demonstrated in more than 10 murine models of disease for targets in the NF-κB family, various members of the ETS transcription factor family, and targets in the JNK and TAM pathways.

About Altamira Therapeutics

Altamira Therapeutics (NASDAQ:CYTO) is dedicated to developing therapeutics that address important unmet medical needs. The Company is currently active in three areas: the development of RNA therapeutics for extrahepatic therapeutic targets (OligoPhore™ / SemaPhore™ platforms; preclinical), nasal sprays for protection against airborne viruses and allergens (Bentrio™; commercial) or for the treatment of vertigo (AM-125; Phase 2), and the development of therapeutics for intratympanic treatment of tinnitus or hearing loss (Keyzilen® and Sonsuvi®; Phase 3). Founded in 2003, it is headquartered in Hamilton, Bermuda, with its main operations in Basel, Switzerland. For more information, visit: https://altamiratherapeutics.com/

Forward-Looking Statements

This press release may contain statements that constitute “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements are statements other than historical facts and may include statements that address future operating, financial or business performance or Altamira Therapeutics’ strategies or expectations. In some cases, you can identify these statements by forward-looking words such as “may”, “might”, “will”, “should”, “expects”, “plans”, “anticipates”, “believes”, “estimates”, “predicts”, “projects”, “potential”, “outlook” or “continue”, or the negative of these terms or other comparable terminology. Forward-looking statements are based on management’s current expectations and beliefs and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. These risks and uncertainties include, but are not limited to, the approval and timing of commercialization of AM-301, Altamira Therapeutics’ need for and ability to raise substantial additional funding to continue the development of its product candidates, the timing and conduct of clinical trials of Altamira Therapeutics’ product candidates, the clinical utility of Altamira Therapeutics’ product candidates, the timing or likelihood of regulatory filings and approvals, Altamira Therapeutics’ intellectual property position and Altamira Therapeutics’ financial position, including the impact of any future acquisitions, dispositions, partnerships, license transactions or changes to Altamira Therapeutics’ capital structure, including future securities offerings. These risks and uncertainties also include, but are not limited to, those described under the caption “Risk Factors” in Altamira Therapeutics’ Annual Report on Form 20-F for the year ended December 31, 2021, and in Altamira Therapeutics’ other filings with the SEC, which are available free of charge on the Securities Exchange Commission’s website at: www.sec.gov. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those indicated. All forward-looking statements and all subsequent written and oral forward-looking statements attributable to Altamira Therapeutics or to persons acting on behalf of Altamira Therapeutics are expressly qualified in their entirety by reference to these risks and uncertainties. You should not place undue reliance on forward-looking statements. Forward-looking statements speak only as of the date they are made, and Altamira Therapeutics does not undertake any obligation to update them in light of new information, future developments or otherwise, except as may be required under applicable law.

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SOURCE: Altamira Therapeutics Ltd.

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