Neuropathix, Inc. Announces Publication of Its Global PCT Patent for NPTX-204, a Novel Hops-Inspired Neuroprotectant

DOYLESTOWN, Pa., Jan. 19, 2021 (GLOBE NEWSWIRE) — Neuropathix, Inc. (“Neuropathix” or the “Company”) (OTCQB: NPTX), a socially responsible pain management life sciences company, announced the publication of its global WIPO/PCT Patent WO 2020/ 264324 – “Use of Certain Phosphatidylcholines Containing Long Chain Polyunsaturated Fatty Acids (“PUFAs”) as Neuroprotective Agents” (the “PUFA Patent”).

The invention underlying the PUFA Patent relates to the pharmaceutical composition comprising an amount of phosphatidylcholine (“PC”) containing long chain polyunsaturated fatty acids as neuroprotective agents and to compositions and methods comprising the same (“NPTX-204”). It has surprisingly been discovered that certain PCs containing PUFAs exhibit neuroprotective effects on neuronal tissues subjected to oxidative stress. NPTX-204 and other PCs demonstrated neuroprotective effects in maintaining neuronal viability and preventing neuronal cell death in hippocampal cultures subjected to ethanol toxicity during the Company’s in vitro pre-clinical studies.

The invention also relates to compositions or formulations that comprise of NPTX-204 and other PCs of the PUFA Patent to treat and prevent oxidative stress in neuronal tissues, particularly neuronal tissues of the central nervous system (“CNS”). Additionally, the Company believes that NPTX-204 and other PCs of the PUFA Patent may serve as a vehicle for adjunct, combination or synergistic therapy of PCs of the PUFA Patent with additional active agents.

“In June 2013, during the Company’s attendance at the International Cannabinoid Research Society (ICRS) annual conference in Vancouver, BC, I turned to my colleagues Doug Brenneman and Bill Kinney and said, ‘Hops, I believe hops is related to cannabis. And that being the case, could there be a neuroprotective agent in hops along the lines as cannabidiol (CBD) is to cannabis?’ The answer to that question is ‘yes.’ Through our pre-clinical pharmacology studies, we then asked native hippocampal neurons, ‘What protects you more from severe ethanol toxicity, CBD or NPTX-204?’ These neurons told us, ‘NPTX-204.’ In fact, the _EC50 of NPTX-204 is over 3 million times more potent than CBD. That’s femtomolar range. That’s ‘pharmaceutical like’ at the hormonal level. As was the case with KLS-13019, our globally patented neuroprotectant, we are bolstering our global IP estate with NPTX-204, a newly discovered compound inspired by cannabis’ brew-fermented cousin, humulus lupulus, aka, hops,” said Dean Petkanas, CEO of Neuropathix, Inc.

About Neuropathix, Inc.

Neuropathix is a biopharmaceutical company focused on the research and development of a pipeline of next generation, socially responsible pain management and neuroprotective therapeutics to treat patients with significant unmet medical needs. Over the past ten years, Neuropathix has discovered, developed, and patented a global intellectual property estate, led by its lead clinical target, KLS-13019, as novel, new therapeutic agents designed to prevent and reverse neuropathic pain, reduce oxidative stress, and act as anti-inflammatory neuroprotectants. The Company’s family of patented monotherapeutic molecules focuses on treating oxidative stress-related diseases, chronic pain management, and neurodegenerative disorders. The therapeutic targets include chemotherapy-induced peripheral neuropathy (CIPN), a chronic neuropathy caused by toxic chemotherapeutic agents; hepatic encephalopathy (HE), a neurotoxic brain-liver disorder caused by excessive concentrations of ammonia and ethanol in the brain; mild traumatic brain injury (mTBI), a disorder associated with single and repetitive impact injuries; and chronic traumatic encephalopathy (CTE), a disease associated with highly repetitive impact injuries in professional and amateur sports. Neuropathix conducts its research and development efforts at the Pennsylvania Biotechnology Center of Bucks County in Doylestown, PA.

For more information about Neuropathix, visit www.neuropathix.com and the Company’s Twitter page at @neuropathix.

Forward-Looking Statements
This press release may contain certain forward-looking statements and information, as defined within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and is subject to the Safe Harbor created by those sections. This press release contains statements about expected future events, the Company’s business plan, plan of operations, the viability of the Company’s drug candidates, the targeted beneficial effects of the PUFA Patent, the Company’s position, and/or financial results that are forward-looking in nature and subject to risks and uncertainties. Such forward-looking statements, by definition, involve risks and uncertainties. The Company does not sell or distribute any products that are in violation of the United States Controlled Substances Act.

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