PRAGUE, Czech Republic, June 04, 2021 (GLOBE NEWSWIRE) — SOTIO, a clinical stage immune-oncology company owned by PPF Group, today announced the presentation of positive biomarker data from its Phase 2 trial with dendritic cell vaccine DCVAC/OvCa during a virtual poster presentation at the 2021 ASCO Annual Meeting. DCVAC/OvCa is being developed as a first line treatment in adults with ovarian cancer. The data demonstrate signs of efficacy and safety of DCVAC/OvCa combined with chemotherapy in patients with newly diagnosed epithelial ovarian carcinoma and provide strong rationale for potential study in larger clinical trials.
Data highlights from the poster entitled, “Dendritic cell vaccine (DCVAC) combined with chemotherapy in patients with newly diagnosed epithelial ovarian carcinoma after primary debulking surgery: Biomarker exploratory analysis of a phase 2, open-label, randomized, multicenter trial” include:
“The data presented from the Phase 2 study of our DCVAC cell therapy candidate, DCVAC/OvCa, further support SOTIO’s platform and approach to developing improved immunotherapies for cancer treatment,” said Radek Spisek, PhD., chief executive officer of SOTIO. “Our data indicate a potentially strong effect of DCVAC/OvCa in patients with ovarian cancer, predominantly in patients with immunologically cold tumors, which showed to be refractory in clinical trials with immunotherapy so far. We look forward to continued development of this unique cell therapy.”
SOTIO’s DCVAC Program is a cell therapy platform designed to improve efficacy compared to earlier generations of dendritic cell therapies by targeting multiple antigens and applying an immune-stimulatory technique. SOTIO has created this vertically integrated, personalized cell therapy platform to enable the efficient manufacturing of product doses for one year of treatment at commercially attractive costs.
A copy of the presentation materials can be accessed on the SOTIO website, and a recorded oral presentation focused on the data will be hosted on the online ASCO Media Library. The abstract can be found in the ASCO Meeting Library, linked here: https://meetinglibrary.asco.org/record/195562/abstract
About SOV01 clinical trial:
SOV01 is a randomized, open-label, three-arm multicenter Phase 2 clinical trial evaluating DCVAC/OvCa in combination with first-line standard chemotherapy in women with newly diagnosed epithelial ovarian cancer following radical debulking surgery.
Company contact: | Media contact: |
Richard Kapsa | Michael Tattory |
Head of Communication | LifeSci Communications |
T: (+420) 224 174 448 | T: +1 (646) 751-4362 |
M: (+420) 603 280 971 | mtattory@lifescicomms.com |
kapsa@sotio.com | |
About SOTIO
SOTIO is shaping the future of cancer immunotherapies by translating compelling science into patient benefit. SOTIO’s robust clinical pipeline includes a differentiated superagonist of the attractive immuno-oncology target IL-15, a platform to streamline personalized active immune cell therapies, CAR T platform and a new generation of potent and stable antibody-drug conjugates (ADCs). SOTIO is a member of the PPF Group. For more information, please visit the company’s website at www.sotio.com.
SOTIO is a registered trademark of SOTIO a.s. in selected countries.
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