WALTHAM, Mass., June 18, 2021 (GLOBE NEWSWIRE) — Entasis Therapeutics Holdings Inc. (NASDAQ: ETTX), a clinical-stage biopharmaceutical company focused on the discovery and development of novel antibacterial products, today announced multiple presentations at the World Microbe Forum 2021, taking place virtually June 20-24. Entasis will present 11 posters with one oral presentation highlighting ETX0462, a novel, first-in-class, diazabicyclooctane with antimicrobial activity against Pseudomonas aeruginosa. Presentations will also include updates on SUL-DUR, a β-lactam/β-lactamase inhibitor currently in a Phase 3 registrational clinical trial to treat infections caused by carbapenem-resistant Acinetobacter baumannii, and ETX0282CPDP, an oral β-lactam/β-lactamase inhibitor being developed to treat multidrug-resistant Gram-negative pathogens, including those caused by extended-spectrum β-lactamases (ESBLs) and carbapenem-resistant Enterobacteriaceae (CRE).
The details of the presentations are as follows:
SUL-DUR Presentations:
Poster: Outer membrane permeability and efflux do not limit antibacterial activity of sulbactam-durlobactam in Acinetobacter baumannii
Session: AAR09 Pharmacological Studies of Investigational Agents Pre-NDA
Poster Number: WMF21-0322
Poster: Effect of Susceptibility Testing Conditions on the In Vitro Antibacterial Activity of Sulbactam-Durlobactam
Session: AAR09 Pharmacological Studies of Investigational Agents Pre-NDA
Poster Number: WMF21-0325
Poster: Sulbactam-Durlobactam MIC and Disk Diffusion Quality Control Ranges Using a CLSI M23-A4 Study Design
Session: AAR09 Pharmacological Studies of Investigational Agents Pre-NDA
Poster Number: WMF21-0326
ETX0282CPDP Presentation:
Poster: The β-lactamase inhibitor ETX1317 restores the activity of cefpodoxime against recent (2017-2019), geographically diverse drug-resistant Enterobacterales isolates
Session: AAR08 New Antimicrobial Agents (in vitro and in vivo Studies Prior to the Start of Clinical Therapeutic Studies/pre-Phase 2)
Poster Number: WMF21-0290
ETX0462 Presentations:
Oral Presentation: The Discovery of the Novel Diazabicyclooctane (DBO) ETX0462: A Single Antibacterial Agent to Treat Gram-negative Infections, Including MDR Pseudomonas aeruginosa
Session: AAR107 New Agents Discovery Summary Session: Early New Antimicrobial Agents
Date and Time: Monday, June 21, 2021, 11:00am-12:30 pm
Poster: ETX0462 Inhibits Penicillin-Binding Protein 3 of Pseudomonas aeruginosa and Escherichia coli
Session: AAR08 New Antimicrobial Agents (in vitro and in vivo Studies Prior to the Start of Clinical Therapeutic Studies/pre-Phase 2)
Poster Number: WMF21-0287
Poster: ETX0462 is a Novel PBP Inhibitor with Potent Activity against Recent, Global, Gram-Negative, Clinical Isolates
Session: AAR08 New Antimicrobial Agents (in vitro and in vivo Studies Prior to the Start of Clinical Therapeutic Studies/pre-Phase 2)
Poster Number: WMF21-0293
Poster: The Novel, Non-β-lactam PBP Inhibitor, ETX0462, Retains Potent Antibacterial Activity Across Isogenic Panels of Gram-negative Resistant Determinants
Session: AAR08 New Antimicrobial Agents (in vitro and in vivo Studies Prior to the Start of Clinical Therapeutic Studies/pre-Phase 2)
Poster Number: WMF21-0288
Poster: ETX0462, a Novel Non β-lactam PBP Inhibitor, Is Bactericidal Against Gram negative pathogens with a Low Propensity for Mutant Generation
Session: AAR08 New Antimicrobial Agents (in vitro and in vivo Studies Prior to the Start of Clinical Therapeutic Studies/pre-Phase 2)
Poster Number: WMF21-0286
Poster: Evaluation of the Pharmacokinetics/Pharmacodynamics (PK/PD) of the Novel Diazabicyclooctane (DBO) ETX0462 Against Pseudomonas aeruginosa Infections, Including MDR Strains
Session: AAR07 Antimicrobial Pharmacokinetics and Pharmacodynamics
Poster Number: WMF21-0292
Poster: The Novel, Non-β-lactam PBP Inhibitor, ETX0462, Has Potent Activity Against Biothreat Pathogens In Vitro and In Vivo
Session: AAR08 New Antimicrobial Agents (in vitro and in vivo Studies Prior to the Start of Clinical Therapeutic Studies/pre-Phase 2)
Date and Time: WMF21-0312
About Entasis Therapeutics Inc.
Entasis is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel antibacterial products to treat serious infections caused by multidrug-resistant Gram-negative bacteria. Entasis’ pathogen-targeted design platform has produced a pipeline of product candidates, including SUL-DUR (targeting Acinetobacter baumannii infections), zoliflodacin (targeting Neisseria gonorrhoeae infections), ETX0282CPDP (targeting Enterobacteriaceae infections) and ETX0462 (targeting Pseudomonas infections). For more information, visit www.entasistx.com.
Company Contact | Investor Contact | |
Kyle Dow | Bruce Mackle | |
Entasis Therapeutics | LifeSci Advisors | |
(781) 810-0114 | (929) 469-3859 | |
kyle.dow@entasistx.com | bmackle@lifesciadvisors.com |
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