JERSEY CITY, N.J., April 27, 2022 (GLOBE NEWSWIRE) — SCYNEXIS, Inc. (NASDAQ: SCYX), a biotechnology company pioneering innovative medicines to overcome and prevent difficult-to-treat and drug-resistant infections, today announced several poster presentations highlighting details from interim analyses of data from its ongoing Phase 3 FURI and CARES studies investigating the potential of ibrexafungerp as a treatment for invasive candidiasis (IC) and candidemia, including infections caused by Candida auris (C. auris). The posters were presented at the 32nd Annual European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) held in Lisbon, Portugal April 23-26, 2022.
“We are excited to share these latest data with the medical community as we advance our hospital clinical programs in invasive candidiasis, including candidemia,” said David Angulo, M.D. Chief Medical Officer of SCYNEXIS. “There is great unmet need for additional therapies to fight these infections, which can be quite serious, especially if the pathogen is resistant to current therapies, as can be the case with C. auris. We are proud to be a part of this important research.”
C. auris, a contagious fungal infection that can quickly spread in patients in hospital wards or nursing home facilities, has been designated as an “urgent threat” by the CDC.2 Invasive C. auris infections have a high mortality rate – more than one in three patients can die.3
“Many C. auris strains are resistant to at least two classes of antifungals, which makes these interim research findings of ibrexafungerp’s activity against this terrible pathogen so promising,” said Marco Taglietti, M.D., President and Chief Executive Officer of SCYNEXIS. “The reported outbreak of C. auris at a specialty hospital in Detroit just last week underscores the urgency of finding new treatment options to battle this ongoing dangerous fungal public health threat.”
Below are highlights of the posters presented:
SCYNEXIS scientific posters, including those presented at ECCMID, are available on the corporate website here.
About Ibrexafungerp
Ibrexafungerp [pronounced eye-BREX-ah-FUN-jerp] is an antifungal agent and the first representative of a novel class of structurally-distinct glucan synthase inhibitors, triterpenoids. This agent combines the well-established activity of glucan synthase inhibitors with the potential flexibility of having oral and intravenous (IV) formulations. Ibrexafungerp is in late-stage investigation and development for multiple indications, including life-threatening fungal infections caused primarily by Candida (including C. auris) and Aspergillus species in hospitalized patients. It has demonstrated broad-spectrum antifungal activity, in vitro and in vivo, against multidrug-resistant pathogens, including azole- and echinocandin-resistant strains. The U.S. Food and Drug Administration (FDA) granted Qualified Infectious Disease Product (QIDP) and Fast Track designations for the oral and IV formulations of ibrexafungerp for the indications of invasive candidiasis (IC), including candidemia, and invasive aspergillosis (IA) and has granted Orphan Drug Designation for the IC and IA indications. The European Medicines Agency (EMA) has granted ibrexafungerp Orphan Medicinal Product designation for the indication of IC. Ibrexafungerp is formerly known as SCY-078.
About SCYNEXIS
SCYNEXIS, Inc. (NASDAQ: SCYX) is a biotechnology company pioneering innovative medicines to help millions of patients worldwide overcome and prevent difficult-to-treat infections that are becoming increasingly drug-resistant. SCYNEXIS scientists are developing the company’s lead asset, ibrexafungerp (formerly known as SCY-078), as a broad-spectrum, systemic antifungal for multiple fungal indications in both the community and hospital settings. SCYNEXIS has initiated the launch of its first commercial product in the U.S., BREXAFEMME® (ibrexafungerp tablets). The U.S. Food and Drug Administration (FDA) approved BREXAFEMME on June 1, 2021. In addition, late-stage clinical investigation of oral ibrexafungerp for the prevention of recurrent vulvovaginal candidiasis (VVC) and the treatment of life-threatening invasive fungal infections in hospitalized patients is ongoing. For more information, visit www.scynexis.com.
CONTACT:
Investor Relations
Irina Koffler
LifeSci Advisors
Tel: (646) 970-4681
ikoffler@lifesciadvisors.com
Media Relations
Gloria Gasaatura
LifeSci Communications
Tel: (646) 970-4688
ggasaatura@lifescicomms.com
1 USA Today. April 21, 2022. https://www.usatoday.com/story/news/nation/2022/04/21/candida-auris-detroit-hospital/7394202001/. Accessed April 2022.
2 U.S. Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States 2019. Revised December 2019. https://www.cdc.gov/drugresistance/biggest-threats.html. Accessed April 2022.
3 U.S. Centers for Disease Control and Prevention. Candida auris: A Drug-resistant Germ That Spreads in Healthcare Facilities. Revised December 2018. https://www.cdc.gov/fungal/candida-auris/c-auris-drug-resistant.html. Accessed April 2022.
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