Presentation highlights a novel target identified for Alzheimer’s disease using Cerevance’s proprietary NETSseq platform
Cerevance’s THIK-1 targeting inhibitor, C101248, demonstrated positive results in human and mouse cell based and electrophysiology assays relevant to neuroinflammation in neurodegenerative disease
Data has been concurrently published in the peer-reviewed journal, Neuropharmacology
BOSTON, Nov. 30, 2022 (GLOBE NEWSWIRE) — Cerevance, a private, clinical-stage drug discovery and development company focused on central nervous system (CNS) diseases, today announced the presentation of preclinical data supporting the use of the company’s Nuclear Enriched Sort sequencing (NETSseq) technology platform to identify novel, druggable targets involved in the regulation of neuroinflammation in Alzheimer’s disease (AD). The data will be presented during the CSHL Neurodegenerative Disease – Biology and Therapeutics Conference held at the Cold Spring Harbor Laboratory from November 30 – December 2, 2022.
In addition, this data has been published in the peer-reviewed journal Neuropharmacology. The article, titled, “Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome,” is available on the publisher’s website.
“The recent preclinical data and subsequent publication are incredibly important in further validating NETSseq’s ability to uncover never-before-targeted mechanisms in the treatment of Alzheimer’s disease,” said Mark Carlton, Ph.D., chief scientific officer of Cerevance. “CN101248, the first selective small molecule THIK-1 inhibitor, attacks neuroinflammation via THIK-1 and we have observed beneficial effects on neuroinflammation with this compound. Our development of CN101248 has demonstrated THIK-1’s involvement in inflammatory signaling in microglia, the brain’s immune cells, and serves as a promising avenue of further research.”
The presentation during the CSHL conference, titled, “Using Cerevance’s NETSseq platform to identify targets involved in neuroinflammation in Alzheimer’s disease,” highlights the ability of the company’s NETSseq platform to discover targets affecting inflammatory processes associated with AD.
Key highlights of the presentation include:
About Cerevance
Cerevance is a private pharmaceutical company whose lead therapeutic, CVN424, a first-in-class, oral, non-dopaminergic compound acting on a novel target (GPR6), recently demonstrated significant and clinically meaningful efficacy in a 135-patient Phase 2 study in patients with Parkinson’s disease. The company uses its proprietary NETSseq technology platform to identify highly selectively novel target proteins that are either specific to certain brain circuits or are over- or under-expressed in diseased brains. Partnering with over 25 brain banks and evaluating more than 12,000 human post-mortem brain tissue samples, Cerevance is advancing a robust pipeline of targeted treatments for patients with neurodegenerative diseases, including Parkinson’s disease, Amyotrophic Lateral Sclerosis and Alzheimer’s disease. For additional information, please visit www.cerevance.com.
Contacts
Cerevance:
Johnna Simoes, ir@cerevance.com
Media:
Andrew Mielach, amielach@lifescicomms.com, +1-646-876-5868
NASHVILLE, Tenn.--(BUSINESS WIRE)--#aesthetics--ObjectiveHealth, a Nashville-based integrated research and technology platform company, announced today that it…
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Anumana, a leading AI-driven health technology company and portfolio company of nference, announced…
AI-powered clinical intelligence, seamless journey automation, and a robust network of behavioral health and medical…
Allele Capitals' Matt Hughes will moderate future forward panel on enterprise need in wearables for…
Recent expansion adds 7,500 square feet to the companies' headquarters LINDON, Utah, June 28, 2024…
Introducing SPINDLE, a pioneering robotic rehabilitation system to enhance daily living activities for individuals with…