REDWOOD CITY, Calif., June 10, 2024 (GLOBE NEWSWIRE) — Ashvattha Therapeutics (“Ashvattha”), a clinical-stage company advancing a new class of nanomedicine therapeutics that traverse tissue barriers to selectively target activated cells in regions of inflammation, today announced the presentation of data demonstrating the therapeutic potential of Ashvattha’s novel CSF1R dendranib for MS based on symptom reduction in a mouse experimental autoimmune encephalitis (EAE) model. This therapeutic effect was further evidenced by a reduction in neuroinflammation by PET imaging using Ashvattha’s proprietary ¹⁸F-OP-801 radiotracer. The oral presentation was delivered by Ashvattha’s collaborator from Stanford University at the Society of Nuclear Medicine & Molecular Imaging (SNMMI) 2024 Annual Meeting in Toronto. The presentation was nominated for a Brain Imaging Council Young Investigator Award.
Key findings from the presentation include the following:
“There continues to be an important unmet medical need for imaging agents that enable monitoring of pathophysiologic and therapeutic responses in neuroinflammatory conditions including MS,” said Michelle L. James, Ph.D., Assistant Professor, Department of Radiology and Department of Neurology and Neurological Sciences, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine. “Our study demonstrated that ¹⁸F-OP-801 enables early detection of neuroinflammation in a well-established preclinical model of MS. Excitingly, the imaging signal and symptoms decreased with CSF1R dendranib treatment, thus warranting further investigation of both the therapy and imaging agent.”
“These results provide preclinical validation for our strategy to develop ¹⁸F-OP-801 as a companion biomarker to treatment with CSF1R dendranib in an image-treat-reimage paradigm for patients with MS as well as other neuroinflammatory conditions,” said Jeff Cleland, Ph.D., CEO of Ashvattha Therapeutics. “In parallel, our Phase 2 study evaluating the ability of ¹⁸F-OP-801 to cross the human blood-brain barrier and selectively target neuroinflammation in patients with multiple sclerosis, amyotrophic lateral sclerosis (ALS), Alzheimer’s disease and Parkinson’s disease is anticipated to have initial results this summer.”
About Ashvattha Therapeutics
Ashvattha Therapeutics is advancing a new class of clinical-stage nanomedicine therapeutics that traverse tissue barriers to selectively target activated cells only in regions of inflammation. Our targeted nanomedicine approach seeks to redefine precision medicine, empowering a new standard of care across ophthalmology, neurology, and inflammation. For more information, visit: www.avttx.com
Media Contact
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mfitzhugh@lifescicomms.com
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