Phenomenex Introduces Biozen™ Native RP-1 and RP-5: A Novel Way to Characterize ADCs with Unmatched Throughput and High-Quality Data

First of its Kind in Biotherapeutic Antibody Characterization

TORRANCE, Calif., March 25, 2025 /PRNewswire/ — Phenomenex Inc., a global leader in the research and manufacture of advanced technologies for the separation sciences, proudly announces the launch of Biozen Native RP-1 and RP-5. As Antibody-Drug Conjugates (ADCs) continue to emerge as a pivotal approach in targeted cancer therapeutics, the demand for precise and efficient characterization methods is increasing. These innovative chromatography columns are designed to transform ADC characterization through reversed-phase separation under native conditions, allowing online mass spectrometry (MS) detection.

“Our team is excited by the advanced ADC characterization capabilities enabled by this new, first of its kind, native reversed phase chromatography product, Biozen Native RP,” says Carl Sanchez, principal scientist of Research and Development at Phenomenex. “This product provides more rapid access to advanced insights into ADC chemistry allowing faster lead identification and optimization.”

The proprietary RP-1 and RP-5 particle technology and surface chemistry allow rapid and robust native reversed phase resolution of all Drug to Antibody Ratio (DAR) species, including positional isomers while facilitating faster and more efficient analyses compared to traditional methods. The newly designed particle allows for reduction in run times and sample manipulation, ensuring that laboratories can achieve higher quality data for ADCs using these advancements in chromatographic media and methods.

This latest innovation from Phenomenex is part of our commitment to being a leader in chromatography solutions, empowering researchers and scientists with tools tailored to advance the frontiers of biotherapeutics.

Additional Resources

• Learn more about the Biozen Native RP-1 and RP-5 columns
• Keep your new columns optimized by reading the Biozen Column Care & Use Manual

About Phenomenex
Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in academic, pharmaceutical, biotech, environmental, clinical research, government, and industrial laboratories. From drug discovery and pharmaceutical development to food safety and environmental analysis, Phenomenex chromatography solutions accelerate science and help researchers improve human health and well-being. Phenomenex is an operating company within the Life Sciences group of Danaher Corporation.

For more information, please visit www.phenomenex.com and follow the company’s blog at www.scienceunfiltered.com.

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SOURCE Phenomenex