180 Life Sciences Corp. Announces Collection of All Patient Data for Phase 2b Dupuytren’s Disease Trial
MENLO PARK, Calif., April 20, 2021 (GLOBE NEWSWIRE) — 180 Life Sciences Corp. (NASDAQ: ATNF) (180 Life Sciences or the “Company”), a clinical-stage biotechnology company focused on the development of novel drugs that fulfill unmet needs in inflammatory diseases, fibrosis and pain, today announced that all patient data for the Phase 2b Dupuytren’s disease clinical trial has been collected and submitted for analysis and review.
The trial is sponsored by the University of Oxford and funded by the Wellcome Trust and UK Department of Health with a contribution from 180 Life Sciences. In this double-blind placebo-controlled trial, 181 patients were randomized across 3 sites, two in the UK and one in the Netherlands. The nodule was injected on up to four occasions at three-month intervals with 40mg adalimumab in 0.4ml or an equivalent volume of placebo, and the patients followed for a further 6 months. Follow up was delayed by the COVID-19 pandemic. The data is currently being analyzed and is planned to be published in a peer-reviewed journal in an open access format. At that stage the Company will announce the top line data.
Dr. James Woody, 180 Life Sciences Chief Executive Officer commented, “Despite the challenges posed by the COVID-19 pandemic and shut down of clinical sites across Europe due to government restrictions, we are fortunate to have had our investigators with the help of additional support from the Wellcome Trust, complete the collection of data. The data is being reviewed and validated, which is not an easy task under current conditions. The analysis will be according to the previously agreed Statistical Analysis Plan. We remain on track to announce a top-line data read out from this trial in Q4 2021.”
Currently there is no approved therapeutic for preventing early stage Dupuytren’s disease and patients who develop finger contractures can struggle with many activities of daily living. Treatments for late-stage disease all have significant shortcomings.
About 180 Life Sciences Corp.
180 Life Sciences Corp. is a clinical-stage biotechnology company focused on the development of novel drugs that fulfill unmet needs in inflammatory diseases, fibrosis and pain by leveraging the combined expertise of luminaries in therapeutics from Oxford University, the Hebrew University and Stanford University. 180 Life Sciences is leading the research into solving one of the world’s biggest drivers of disease – inflammation. The Company is driving groundbreaking studies into clinical programs, which are seeking to develop novel drugs addressing separate areas of inflammation for which there are no effective therapies. The Company’s primary platform is a novel program to treat fibrosis using anti-TNF (tumor necrosis factor).
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Investors:
Jason Assad
Director of IR
180 Life Sciences Corp
(678) 570-6791
Jassad@180lifesciences.com
Media Relations:
David Schull
David.Schull@russopartnersllc.com
(212) 845-4271
