Zenith Epigenetics Announces Appointment to Board of Directors and Provides Clinical Update
CALGARY, Alberta, Jan. 31, 2022 (GLOBE NEWSWIRE) — Zenith Capital Corp. (“Zenith” or the “Company”) today announced the appointment of Dr. Brad Thompson, PhD, to its board of directors.
Dr. Thompson is an experienced biotechnology founder and executive having served as a public company CEO for 22 years. He has served as Chairman, Director, and an Audit Committee member on a number of public company (NASDAQ, TSX and CDNX) boards of directors, and has served as a Director of private company boards and industry groups (including Chairman and Chairman Emeritus of BIOTECanada). He has taken companies public on the TSX, NASDAQ and former Alberta Stock Exchange, as well as led successful cross-listings (from the TSX to the NASDAQ). Dr. Thompson holds a PhD in Microbiology and Immunology from the University of Western Ontario. Prior to entering the private sector, his research affiliations included working with NASA and the Canadian Space Agency, the United Nations, Colorado State University, and the University of Alberta.
“We are very pleased to welcome Dr. Thompson to our Board of Directors, a deeply experienced biotech businessperson who brings a wealth of varied experience, which will assist in further advancing Zenith,” stated Mr. Donald McCaffrey, President & CEO of Zenith.
“I am thrilled to be joining Zenith at such an exciting time in the clinical development of its lead compound ZEN-3694,” said Dr. Thompson. “With such a broad clinical program offering, including multiple promising opportunities to improve the lives of oncology patients, I am looking forward to seeing what comes next from this impressive program.”
Dr. Thompson’s appointment coincides with Dr. Eldon Smith having stepped down from the Board of Directors, effective today. Dr. Smith served on Zenith’s board from its inception in 2013.
“We have immense gratitude for Dr. Smith’s many contributions, guidance, and expertise over the years, which contributed greatly to moving our programs forward. We would like to express our sincere appreciation to him for all of his years of service, and we wish him all the best,” stated Mr. McCaffrey.
Clinical Update
Zenith Epigenetics is developing various novel combinations of BET inhibitors with other targeted agents for numerous oncology indications in pre-selected or enriched patient populations. Our lead compound, ZEN-3694 is undergoing clinical development in multiple clinical trials:
| 1. Phase 2b metastatic castration resistant prostate (mCRPC) cancer trial in combination with androgen receptor inhibitor, XTANDI (enzalutamide): | |
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| 2. Phase 2b Triple Negative Breast Cancer (TNBC) trial in combination with the PARP inhibitor TALZENNA (talazoparib): | |
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| 3. Phase 1b/2 androgen receptor independent mCRPC trial in combination with immune checkpoint inhibitor KEYTRUDA (pembrolizumab) and XTANDI: | |
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| 4. Phase 1b/2 ovarian cancer trial in combination with immune-checkpoint inhibitors, nivolumab and ipilimumab: | |
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| 5. Phase 1b/2 NUT carcinoma trial in combination with chemotherapy: | |
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| 6. Phase 1b/2 solid tumors and lymphoma trial in combination with entinostat: | |
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About Zenith
Zenith Capital Corp. is a biotechnology investment company originally spun out of Resverlogix Corp. (TSX: RVX) in 2013. Zenith Epigenetics Ltd., a wholly-owned subsidiary of Zenith Capital Corp., is a clinical stage biotechnology company focused on the discovery and development of novel therapeutics for the treatment of cancer and other disorders with significant unmet medical need. Zenith Epigenetics is developing various novel combinations of BET inhibitors with other targeted agents. The lead compound, ZEN-3694, is in clinical development for various oncologic indications, specifically: mCRPC in combination with androgen receptor inhibitor, XTANDI; Triple Negative Breast Cancer in combination with the PARP inhibitor TALZENNA; Androgen receptor independent mCRPC in combination with immune checkpoint inhibitor KEYTRUDA and XTANDI; Ovarian cancer in combination with immune-checkpoint inhibitors, nivolumab and ipilimumab; NUT midline carcinoma in combination with chemotherapy; solid tumors and lymphoma in combination with entinostat.
For further information, please contact:
Investor Relations & Communications
Zenith Capital Corp.
Phone: 587-390-7865
Email: info@zenithepigenetics.com
Website: www.zenithepigenetics.com
This news release may contain certain forward-looking information as defined under applicable Canadian securities legislation, that are not based on historical fact, including without limitation statements containing the words “believes”, “anticipates”, “plans”, “intends”, “will”, “should”, “expects”, “continue”, “estimate”, “forecasts” and other similar expressions. In particular, this news release includes forward looking information relating to the potential role of ZEN-3694 in the treatment of cancer and other disorders, and the Company’s development of ZEN-3694 including its current and planned clinical studies. Our actual results, events or developments could be materially different from those expressed or implied by these forward-looking statements. We can give no assurance that any of the events or expectations will occur or be realized. By their nature, forward-looking statements are subject to numerous assumptions and risk factors including those discussed in our most recent MD&A which are incorporated herein by reference and are available through SEDAR at www.sedar.com. The forward-looking statements contained in this news release are expressly qualified by this cautionary statement and are made as of the date hereof. Zenith disclaims any intention and has no obligation or responsibility, except as required by law, to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
