Avenda Health Expands Unfold AI Platform to Support Intraoperative Prostate Cancer Care

Surgery Mode brings patient-specific 3D cancer estimation maps directly into the operating room, giving surgeons an enhanced view of cancer anatomy during robotic prostate procedures

• Moving beyond pre-surgical consults, Surgery Mode allows physicians to bring Unfold AI into the operating room for live operational guidance.
• Platform expansion includes an updated Capsule Risk Score map that automatically flips its left/right visual orientation to align with the surgical camera view, providing real-time risk feedback by quadrant to help surgeons make precise nerve-sparing decisions.
• Unfold AI supports clinical decision-making across active surveillance, focal therapy, radiation oncology, and surgical procedures.

CULVER CITY, Calif., Oct. 20, 2026 /PRNewswire/ — Avenda Health, an AI healthcare company creating the future of personalized prostate cancer care, today announced Surgery Mode, a new suite of intraoperative features for Unfold AI. This multimodal AI-powered prostate cancer mapping platform is designed to reveal the true size and extent of disease to help physicians make better informed treatment decisions.

Surgery Mode enhances how surgeons use 3D AI mapping during non-robotic and robotic surgeries, alongside new platform tools that simplify patient case management and physician workflows. The launch builds on peer-reviewed research predicting Unfold AI could cut positive surgical margins in half, substantially reducing cancer recurrence. In the study, Unfold AI outperformed MRI and other modalities in assessing whether cancer had spread beyond the prostate, assisting surgeons in making nerve-sparing decisions.

In Surgery Mode, physicians can now access enlarged 3D views for clearer visualization, adjust the cancer estimation map to match the camera angle on the surgical console, review underlying MRI slices during the procedure, and access capsule risk scores from within a dedicated surgical view. Unfold AI is the only platform implementing multimodal AI to analyze a patient’s MRI, biopsy, pathology, and PSA together, producing a personalized 3D map of the cancer’s extent to provide surgeons with more precise visualization of tumor boundaries.

While Unfold AI has long served as a decision-support tool during preoperative consultations, the latest expansion gives surgeons an enhanced version of these maps during surgical prostate procedures. The suite of improved workflow tools also gives physicians and staff greater visibility into the status of each patient case.

Other key features of the new update include:

• Aligned Capsule Risk Score mapping: The Capsule Risk Score overlay now automatically flips its left/right visual orientation to mirror the surgical camera view, giving surgeons immediate, color-coded risk feedback by quadrant to guide precise nerve-sparing decisions in real time.
• Redesigned patient list and case filters: Improved patient organization and updated case status labels let users search for cases in progress, add new patients, and filter by status to see where each case stands at a glance.
• Improved administrative control: New built-in tools let staff verify insurance approvals and confirm administrative steps are complete before 3D map generation.
• Streamlined case management: Care teams can now add and view patient notes directly from the patient list and update the assigned physician on a patient report.

“Our goal with Unfold AI has always been to provide more clinical clarity throughout every stage of a patient’s cancer journey,” said Shyam Natarajan, Ph.D., co-founder and CEO of Avenda Health. “Whether a physician is counseling a newly diagnosed patient, planning a targeted radiation oncology treatment, or performing a complex radical prostatectomy, having an accurate 3D map of the disease is transformative. These new surgical enhancements empower physicians with the visual confidence needed to achieve optimal cancer control while protecting patient quality of life during complex procedures.”

The expanded features  extend Unfold AI’s reach across the prostate cancer care pathway, including active surveillance, focal therapy, surgical interventions, and radiotherapy. Its interactive 3D maps serve as a powerful visual guide for patient counseling and decision support, helping patients and physicians confidently select their treatment path. Now, with Surgery Mode, the same patient-specific mapping technology can also be used to provide clear visual boundaries in the operating room, actively guiding surgical procedures such as robotic prostatectomies.

Unfold AI predicts the cancer’s spread into nearby anatomy with 92% accuracy, compared to 52% using MRI alone. That spatial clarity is central to helping surgeons determine whether a nerve-sparing or non-nerve-sparing surgery should be performed. Additional research demonstrates that Unfold AI improves physician identification of tumor extent, increasing sensitivity from 37% to 97%. By expanding Unfold AI from preoperative decision support into the operating room, Avenda Health is continuing to develop more precise views of prostate cancer that can support physicians across different stages of care.

For more information on Avenda Health or to find a provider who offers Unfold AI, visit avendahealth.com 

About Avenda Health
Avenda Health is creating a more personalized future of prostate cancer care. Using deep learning, Avenda Health software maps a patient’s cancer in 3D, giving physicians precise information and the confidence to make care decisions. Dedicated to bringing this cutting-edge technology to all practices and physicians treating prostate cancer patients, Avenda Health aims to improve outcomes, preserve quality of life, and create a new standard of cancer care. To learn more, visit: avendahealth.com

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SOURCE Avenda Health